More on the Safety of Turmeric

Study published in Biomed Research International demonstrates the safety of a turmeric polysaccharide extract in terms of mutagenic potential in rats.



Curcuma longa Linn. (Zingiberaceae) commonly known as turmeric has long been used for centuries as a spice and household remedy. The present study was carried out to assess the possible mutagenic potential and acute oral toxicity of polysaccharide extract of turmeric rhizome (NR-INF-02) using standard tests. The standard battery of in vitro genotoxicity tests, bacterial reverse mutation test (BRMT), chromosome aberration (CA), and micronucleus (MN) tests were employed to assess the possible mutagenic activity of NR-INF-02 (Turmacin). The results showed no mutagenic effect with NR-INF-02 up to a dose of 5000 µg/mL in BRMT. The results on CA and MN tests revealed the non clastogenic activity of NR-INF-02 in a dose range of 250.36 to 2500 µg/mL with and without metabolic activation (S9). In acute oral toxicity study, NR-INF-02 was found to be safe up to 5 g/kg body weight in Wistar rats. Overall, results indicated that polysaccharide extract of C. longa was found to be genotoxically safe and also exhibited maximum tolerable dose of more than 5 g/kg rat body weight.

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  1. You know how you just trust the word of elders on remedies just because it’s been a practice in the family for centuries? I think it’s great that this time, there really is more scientific claim on all these long time beliefs on the benefits of turmeric. At least now we know better the safest dose, just really to know how effective turmeric can be used as a remedy. Hopefully, more research can be done then on humans.


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